Endocrine Abstracts

Cardiovascular diseases (CVDs) represent a complex and multifactorial issue that results from a combination of behavioural, genetic and environmental factors. Toxic metal contaminants, many of which act as endocrine disruptors (EDs), have been identified as potential risk factors for CVDs. Among EDs Cadmium (Cd), present both in cigarettes and in food, has been suggested to be cytotoxic on vascular endothelium, likely leading to blood pressure increase and vascular inflammatio...

The highly toxic heavy metal Cadmium (Cd) is widely spread in the environment and could exert estrogen-like activity in tissues including breast. Previous studies demonstrated that Cd binds to estrogen receptor α positive (ERα+) breast cancer (BC) cells. In this new study, we evaluated effects of Cd on both ERα+ and ERα negative (ERα-) BC models with the aim to further characterize the mechanisms involved in Cd-related BC carcinogenesis. Specifically, ...

Introduction: Obesity is a chronic metabolic condition characterized by an excess of adipose tissue leading to an increased risk of developingdiseases such as diabetes mellitus and cardiovascular pathologies. Unbalanced nutrition and sedentary lifestyle are among the main influencing factors leading to a reduction in muscle mass, strength and functionality, predisposing obese subjects to sarcopenia and functional disability. Moreover, recent studies suggest the possible presen...